It very well could be a coincidence that running the new wire and some wire with the hu shorted closely together. He did say the wire was ran a couple of days ago and this problem just started. I'm not saying it's not the power wire, but if it was, there would more than likely be a voltage drop at all times, not just when the radio is on. If that were to short, it would pull enough power to blow the inline fuse. If the fuse didn't blow, the battery would definitely be drained overnight. A wire on the hu could do that as well, but it's not as likely.