it works suitably well with other amps, but having stiff supply regulation and a DF > 10 @ rated load conditions allows the amp to reject load and line variations to a large degree, thus making the testing of the amp based on rated specs @ 14.4V and unloaded give results that are very close to testing with 12V and a 1ohm load on the amp.
I beleive JL's site gives such a warning, though there are many amps out there that work fine.
unregulated amps will have variations based upon supply. if the DF is low, the load will give rise to variations as well. note that many guides suggest the gains be set to allow moderate clipping, conceeding that the penelty for clipping is not death, and for low levels of clipping can be a small penelty.
so DMM settings will cause a little more clipping if the user has a low battery, and a little less when the user has a high battery. or maybe the amp will have minor clipping when the battery is low and will be underutilized when it is high. either way, the method gets you close, and the penelty for being off by a bit isn't very high, so it still works.
the gain adjusts volume, but doesn't limit the user from excessive settings. fully turned is not 100% volume, so while the gain does adjust volume, it is not really a good volume control.
still, a user can set the gain to an arbitrary point, then use the HU to prevent clipping. this is why many people can get very loud at 10/30 on the HU, and then not be able to turn it past 20/30 without distortion. so long as the signal input to the amp is limited consciously by the user, the high gain settings won't cause clipping.