To test to see if the wire at the amp is the wire at your door, do a continuity test from your DMM. Disconnect the wire on both ends. You'll place one prong of the DMM on the neg at your amp and then the other prong on the neg at your speaker (you may have to take a spare piece of wire and connect it to one of the prongs so the DMM can reach both ends of the wire). If the test is true, its the same wire. Try the same test on the pos of the wire and do this for both speaker wire runs. This can help you to make sure it's the same wire and they aren't cut somewhere along the line.
If all tests are true, then with the amp playing a 1KHz test tone (decently high volume, 2/3rd at least) place a DMM at the speaker connectors at the amp, take the voltage reading and then with the tone still playing place the DMM on the speaker wire at the door. If the voltage isn't the same this may indicate a wire that is too small or it is damaged and shorting out. FYI, you can disconnect the neg wire from your rear speakers so they aren't blaring in your ear while you do the test. The sub amp doesn't need to be disconnected because it doesn't play 1Khz.