Biggest thing here is make sure you have enough bracing. I'm currently running a single 18 @ 2500w on a 40x24 baffle, single layer, bolted to the 34"x20" oval trunk opening. Below about 35hz that baffle starts moving. Below 30hz, it's moving enough to be concerning. Any panel above 24x24 should be 1.5" thick or have internal bracing. Any panel over 30x30 should be 1.5" thick and have internal bracing.
My enclosure for the pair of 18's will be about 14 cubes net. It's a really odd shape and 4 of the sides are going to be against the car(rear, bottom, and the 2 large side panels). That leaves the top, the front, and the 2 smaller side panels. The top is going to be 2" thick, the front is going to be 1.5" thick, and the small side panels are going to be .75" thick since they arr only 22"x8". The other panels are going to be either bolted to the car or in the case of the large side panels, wedged between expanding foam and squished by the rear doors.
My subs have very low moving mass, only about 230g. I bet those Z subs are close to double that. That translates into alot of energy transfer into the panel in addition to the air pressure forces.
Matt