I agree there is nothing wrong with playing around and testing, its a good way to learn what sounds good to you, or works and what doesn't.
When I was a young teen I would grab the jigsaw and cut ports in already built boxes and 99% of the time performance was worse, and was even given a couple homemade boxes that sounded like doo-doo with a port the person added and had to plug it for any woofers I put in the box. An exception is when using a sub that requires less airspace and you can add a port tuned properly with no problem. I do have an old Cellbox Soundsystems prefab from the 90's somebody cut a 3" port in the top and plumbed PVC pipe in with an elbow and it sounds better with the port using an old MTX Thunder 6000 10" than the box does sealed, I tried plugging it to see if it sounded better, but the port sounds better (no idea what its tuned to, never measured anything). The low end drops off more with it sealed, but there is a lot of chuffing / airflow through that 3" port. Its in my beat up work truck so doesn't matter.
Point being, nothing wrong with testing, can always seal the holes, it's not that big of a deal. I use to be pretty good at cutting nice circle MDF plugs with the jigsaw to seal the bad port holes I added, even adding small box carpet circles to hide it.

I built and played with a lot of garbage boxes as a teen, you do learn quite a bit from the fails.
But yeah, adding a port to an already built sealed box can be a gamble. External ports might even be the only choice in some instances to get any reasonable tuning. A properly built tuned ported box can be a night and day difference depending on sub and such, if you have the space for it in the vehicle.