old school car audio thought was to keep each sub in segregated enclosures so there is no opportunity to fight against each other.
In order for drivers to share the same cabinet, they need to be identical woofers all running off the same amplifier.
As a relevant aside, the most effective and popular bass cabinet for musicians (made by Ampeg, the world's leader in bass guitar amplficiation and cabinets) is not a dual 18" but is a large cabinet with 8 10" woofers. That cabinet includes shared enclosures and is absolutely, gut wrenchingly potent. There hasn't been a bass cabinet released in the market to beat it in over 30 years, and everyone has tried. They pretty much belong in stadiums, because in clubs of a 1,000 people they will overpower the PA.
In all I would say that the potential for destructive interference increases as the enclosure decreases in size. The example of a bass guitar cabinet isn't the same application; the resonance frequencies are higher, excursion is less and driver efficiencies are far higher. However, physics doesn't change...