That's probably quite true, however, where do you draw the line? If the designer of the Profile has half a clue what he's doing, he specs the components in the amp to make sure that with the widest deviation from the nominal value will still allow it to make all its ratings. That allows the use of cheaper components and keeps the costs down while still allowing the customer to get a known quantity. You know that it will, at WORST, do what it says. Chances are good that it will do better. As far as extra r&d money, seriously doubt it. More advertising money to convice those that listen with their eyes that they must have McIntosh if they want SQ, probably.
As far as long term reliability, at 6x the price it had better last at least 6x as long. Since electronics usually either fail during the warranty period or never (barring abuse) that would be pretty hard to do. I have a bunch of amps from the early 90's that are still working great that, while not budget, were nowhere near the price of the McIntosh.
Sorry I lump "audiophile" amps with outrageous prices in with the same hoodoo as "audiphile" wire. There are much better places to spend your money than either that will actually have an *audible* effect on the system.