When you have multiple speakers playing the same freq range, you want them to couple together as perfectly as possible. If you mount some of them in different sized enclosures, the alignment will be different between the two sets, they will display different frequency to amplitude relationships, the the end result will be a very unpredictable freq response that is probably rather peaky. (also why you generally dont want to mix sub sizes)
Some people have played with relatively complex xover networks to have each different sub play a different bandwidth, with limited success. But this becomes rather messy, and when you consider that a subwoofer really only has to play about 2 octaves (versus many many octaves for mids and tweets), it doesn't make a lot of sense to try to divide those 2 octaves into even more. If your current sub setup has trouble playing those 2 octaves relatively flat, you simply have a problem (or multiple problems) that need to be addressed directly rather than trying such an elaborate work-around.