for most 4ch amps yes you can bridge 1+2 and you can bridge 3+4, making most of those amps "2/3/4" channel amps. You'll need to put the coils of your sub in series for 4 ohms. You can use the 2 other channels for front speakers or something.
As for how to accomplish it, that can vary per amp. Some will connect the negatives, flip a switch, and use the two positives for the speaker output. Some will connect L ch - to R ch + and use the other two for speakers. Some will connect L + to R - and use the other 2 for speakers. etc. Best to look in the amp's manual if it's not silk screened on the amp how to do it.