I think you're getting hung up on the whole 21" thing simply for appearances. Yes it would be cool, it would probably be fairly loud too, but spending $1000 for 2500w of power handling is kind of ridiculous(same goes for $600 for 1500w).
Larger woofers should technically reproduce lower frequencies louder than similar, but smaller subs because they have more cone area and move more air. However, you can achieve similar cone area to an 18" with two 12" woofers. Is it always better to go with more smaller subwoofers instead of less larger woofers? No, because cases like the one discussed earlier in this thread exist. Also, the more subs you buy, typically the more expensive it becomes to match cone area. I could buy one HDC3 18" for $305, or two SA-12's for $400, or three DCON 10's for $450. All of these set-ups have similar cone area, however the HDC3 is the most cone area for the money.
As discussed earlier in this thread as well, cone area is an important factor, but not the only one worth considering. xmax(excursion capability) is another thing to consider, as well as motor strength (the "Bl" value of a sub's T/S parameters). Another T/S parameter that can give you SOME indication as to the response of the woofer is the "Fs" of the woofer, or it's resonant frequency.
Just something to think about.