In order to get the most performance from these non-optimum applications we have taken a different approach. We keep the moving mass low, energy high and add a suspension with high restoring force to help control cone motion. This means that the subs will not have to rely on the box for their loading.
The vehicle itself will offer some loading to the system, and the transfer function will make the system play an octave lower than the tuning freq. So, if you could find some speakers that could stay in control below the box tuning, subs that are really tuned to the box loading plus the car loading, you could design a system to play low. loud and do it in a relatively small box. That is what we designed and spent many years developing.