I ran an older Pioneer GM-6400 for awhile and it worked great running the front channels to apair of Kicker KS comps and the rear bridged to a Polk db104.Depending on the vehicle you may be able to get away with not running the rear speakers at all.I have a Mini so I was able to delete the rear fillsince such a small area. As far as HU options Pioneer will have you covered just be careful some of them have a goofy knob that I found anoying bc it was like a joystick and rotary knob. Goodluck with your set up