Subs and amp randomly quit

When it goes silent, check to see if your amp is in protect (red light) or if it doesn't have power etc. Double check connections

Check all your supply wiring and ground wiring and remote wire.check all your RCA connections..get your alternator bench tested..get your battery bench tested.Check all your fuses and block connections.Pull your sub or subs and check the connections..Check your coils on each sub unwired from the amplifier and independently with a DMM. That would be a start for you.

List you amp, subs, vehicle, and electrical upgrades. Probably clipping it to hell and the amp is shutting down to keep from blowing. Once it cools off it works again.