Breakers are not as safe as fuses in the harsh environment of a vehicle... especially if they ever trip. Each time a breaker trips it arcs and the connection point develops some resistance. Not to mention, breakers don't trip as quickly as fuses blow in a semi low resistance condition. Moreover, breakers are mechanical and thus, are subject to mechanical failure due to dirt infiltrating the internals. In the end, breakers are nice from the perspective of quick disconnect but they are not as safe or as reliable as fuses under the hood of an automobile.
And OP, you can disconnect the power wire, fuse or ground wire and you'll be fine. Just don't do it while the system is playing. ;-)