There is a free box design program called WinISD that will help you model a driver's performance in various sized enclosures. I think it's linearteam.org or something like that.
However, I would simply email CDT and see if you can get some tech help on the issue. I am not telling you that you need to go with sealed and shouldn't port them... in fact, I think porting would be a great thing for midbass drivers, provided you have a good enough high-pass filter on them. I've considered it for mine.
From what you've said, though, worrying about "low end" performance seems a bit... odd to me when you're planning on crossing them over at 100Hz. There is no low end above 100Hz.
If you can get .45 or .5 cubes of airspace, then you can still get those things tuned down to 60 or 70 Hz easily, I would assume, and believe me, that is WORLDS better than crossing several-hundred dollar components at 100Hz. Ugh.
Up-front bass FTMFW!
The .3 sealed box response on that .pdf is probably gonna get a bit of a low-end bump from the car's cabin gain, son don't look at that graph and think it's automatically gonna be wimpy below 100Hz, where it begins to roll off. You could very well go with a .3-.4 sealed box and have those things HAMMERING at 80 or even 60Hz. You might be really really surprised....
What kind of power are you going to be running to these? I assume you're going 3-way active front, since you're only running them up to 350Hz?
Email CDT and tell 'em your dilemma... not QUITE enough airspace for 50Hz tuning, but still want to port. //content.invisioncic.com/y282845/emoticons/wink.gif.608e3ea05f1a9f98611af0861652f8fb.gif
Seriously, though, let me know how they work out in these enclosures, I've got a buddy with these exact drivers who is wanting to build enclosures for his, wondering how they're going to sound. Your experiences could be greatly motivating to him. //content.invisioncic.com/y282845/emoticons/wink.gif.608e3ea05f1a9f98611af0861652f8fb.gif