I have the same amp running my JBL GTI components in my car no problem..
but if you have the amp bridged are you 4ohm? 2 ohm? Your probally pushing 200 RMS easy per ch.. unbridge it.. and try it again see if it happens..
ALso.. unplugging the RCA doesn't mean its the amp.. if it was the amp it might still make the sound.. it could be bad RCA, bad signal, dirty signal.. signal with electrical interference.. so on so forth.. only real way to tell is 1. unbridge it and then try.. 2. try a different RCA cable.. 3. Try a different source 4. try different speakers on the amp..