JL audio, before they even sold wiring, tested a bunch of vehicles in regards to the conductive quality of the vehicle chassis (all vehicles have a chassis not all have a frame). Most unibody vehicles had the conductive properties of 4ga wire. If your main power wire only needs to be 4ga, then you are probably fine with a normal chassis ground. If you are running a bigger setup than that and are bothering with a 1/0 or so power wire, a chassis ground is going to be the weak link in your electrical supply system.
There is a general misconception that the chassis is the vehicle ground. This is plain and simple not the case. The chassis is connected to ground but because it has resistance of its own it is not true ground. The definiton of ground is a point of zero potential. The only part of the car that fits that definiton is the negative post of the battery with the car off and the case (typically) of the alternator with the car on. If you've done a proper "big 3" upgrade, the difference in potential between those two points should be immeasurable and they can be considered as the same from an electrical standpoint.