With a setup like that I'd go sealed, imo..
What do you reccomend? Ported or vented? I'd be tuning it to 35 hz or something, to get good range, sq and loudness. I have no idea how to tune a box, though. Either way I'll make a basic box, then make a removable cover out of fiberglass and some old t-shirts and stuff. The removable covers will be so I have easy access to my stuff when I need to work on it, and will probably just stay in place with velcro or something. Plus that makes doing the actual enclosure much easier.