Running it is not the issue. Ive ran wire many times, just not under the car.. This thread was just to see how many were doing it..I've done it with zero issues...just use common sense and make sure you're not rubbing the wire anywhere, or just use split loom over the whole thing.
i've done it in a 96 lumina before, but since i did it i guess i is dumb. LOLI did it once on my 1981 chevy malibu that I had throughout high school and college in the late 80s early 90s. I ran the wire in a flex steel conduit and used some heavy duty zip ties to channel it in the frame of the car. You just want to make sure there is no way the wire can get pinched by anything or come loose because I wouldn't want to see the aftermath of it snagging on something while I am driving on the interstate....