As a matter of principle, you really want to have all amplifier channels outputting at the same resistance. It's just like your engine will be okay with different compressions in each cylinder, but for ideal operation, matched channels is where you want to go. That said, if the amp is 2 ohm stable (as bones said), there shouldn't be a problem. Only difference is that you'll be sending ~ 2x the power to the 2 ohm speakers.