Do it, why not? You aren't competing or going for an SQ setup right? Just want the most bang for your buck?
Hook em up and let it rip. You only live once, and learn best by doing instead of reading about it on the internet.
Subs are more like grenades than rifles. While yes orientation CAN make a difference, you probably wont be able to tell. I'm assuming you won't have much space to work with using that setup, so put them where they fit best and look decent.
One of my favorite setups I ever had was way back in high school. Two Soundstream USA 10"s and two Nakamichi 8"s. 10's on a bridged Alpine 4 channel, 8"s on a Linear Power ( purple, don't remember model ). Pounded pretty good for what it was.
Now that I'm old I still like going against convention, I'm gearing up to run an single 8" and two 6.5" subs.
-Beau