Well, in case you did not know, your amp is always connected to an 800 amps or more source, depends on your battery size. It is also always connected to a 12v+ source, and no blown fuses.
So when you have a voltage spike, guess what, it pushes(forces) excessive current through a rated fuse, and it pops. It is called Watts/Power, so you cannot have one without the other. If something wacky is going on inside the amp, it will draw more power than needed, and be the source of said spike. Hence the reason I suggested he disconnect his sub amp a few days and see if the spikes continue. If they do, then amp is Obviosly not the source.