Weak spots for pressure losses are the rear hatch, all doors because they can push out. Where the front windshield meets the roof line in the center from left to right-> that's usually a huge flexing problem. Same thing in the rear if you have a trunk or a pickup.
Usually the bottom of the car is solid, usually the firewall is fairly solid (not sure how you'd know). In a big SUV, the rear quarter panels and glass, if they're super long, they can flex very hard.
Adding a lot of mass to the doors is the easiest overall way to keep them from pushing out. Also, if you seal the doors and created a hard wall for your door panel, it makes the air inside of the vehicle hit the wooden wall and put pressure in it, instead of putting pressure on the actual flat sheet metal part of your door. Adds a lot of weight, door becomes harder to push out.
A suburban is so damn long, your roof is going to flex like crazy. I've done a slide in series 6th wall for 2 Fi team 18's, older versions, for a tahoe/suburban. Walls, especially bandpass walls, they have really good properties for hair tricks. You could do a slide in wall, that you could always pull out. The wall will brace the roof for you, if you can build a face for it after you slide it in.
Just some thoughts. I've designed a lot of systems like what you're talking about right here.