Like it has been stated, you fuse the WIRE properly for what it can handle, 50A, so replace it with the proper size fuse.
An 80A fuse will be more 4 gauge territory. If your original 50A fuse did not blow because of playing your system hard enough to where it drew over 50A of current, rather you accidentally grounding your power wire by having it touch the vehicle's chassy or metal, then just simply replace with the same. If your system is drawing more than 50A, then you'll need to upgrade to larger cable and in turn be able to fuse larger.
What does your system consist of BTW?