yes. it can be done, depending on the amp.
Channel 1 - FL and FR speaker = 2 ohm load
Channel 2 - RL And RR speakers = 2 ohm load
Channel 3 and 4 bridged to a 4 ohm load for sub.
Now as it can be done, there are issues.
1. make sure the amp is capable of 2 ohm operation.
2. you will lose either front and rear fade or left and right balance on the speakers.
3. you will a crossover on the sub or speakers, or an amp that can be configure to do that, such as a Phoenix gold XS4600. Im sure there many others that have built in xovers for front and rear channels.
4. You will need a dvc 2 ohm sub wired to 4 ohms on the bridged channels, Most amps are only stable at 4 ohms bridged.
And where did I imply i knew alot..lol.
This is a diagram from section 107 you should read abit on there as well.
http://www.bcae1.com/