Hello,
1. Make sure you have a clean ground. Use sandpaper to take off any paint that is between the body and the ground wire eye terminal, and that the screw is tight.
2. Using a multimeter, test for the resistance between the grounding wire where it connects to the amplifier, and any random places on the car body. You should be reading a few milliohms.
3. Check for ground between the case and the car body. Most amplifiers it shouldn't make a difference. Some, it may, even though it shouldn't. Grounding the amplifier case/heatsink/whatever you wanna call it is a good idea.
4. What happens if you run a 30a fuse in the power wire close to the battery, and a 40a in the amp itself? Which blows first?
Regards,
Josh