I have an S-10 extended cab. What I did was gut the interior, and put about 4 gallons of spectrum sludge over the entire floor, back wall, inner firewall, outer doors, roof, and even did in the wheel wells. I didn't buy the sprayer, but was told that most people just apply it with some sort of puddy knife. I found that just wearing some disposable gloves and applying it by hand was the easiest way to go about it, and in doing so, you are able to feel the contours of the vehicle as well, and try to maintain a uniform thickness. After applying it by hand, you can go back over it with the puddy knife to smooth it out, if you like.
Also, I have to disagree with Squeak to a certain extent on deadening the roof. While I concur that in a car, the trunk will likely be absorbing/vibrating the brunt of the sub's vibrations, the roof of a truck tends to do the same thing...being the large chunk of flexible sheet metal that it is. I hate when you can hear metal (roof or trunk) over the sound of the bass itself. I also did the entire roof with both Sludge and Overkill (closed cell foam), just so that the majority of the sound would stay inside the vehicle, rather than eminate (sp??) throughout the neighborhood...making it more noticeable to would be thieves.
I also got some damplifier Pro, which I put under the hood, on the inner doors (the metal that the panel attatched to), and a few other small places that it seemed easier to do mat than liquid. The hood was recommend by ANT, and one of the first thing I did (before the sludge and everything else), as I was skeptical about any improvement it would make there. After an entire layer of Damplifier was placed under the hood, I started the truck up and really noticed no difference whatsoever (probably due to the sound reflections from bouncing right back up off the driveway). However, I did notice a bit of improvement while driving. Before, alot of the engine noise could be heard coming through at windshield level, but it now was quite deteriorated, and mainly just heard from the sides of the vehicle.
I luckily did not have a ton of rattling in the doors to begin with, as I have a newer vehicle, so I really didn't not notice a ton of difference in this department. I am certain though that over time, without the deadener, the rattles/vibrations would increase greatly over time, as things begin to loosen.
Overkill (neoprene, closed cell barrier) was added to the roof, floor, doors (between panel and metal), inner firewall, and many other little areas like behind the jumpseat, etc. This, in combination with the deadener, made a HUGE difference in road noise, wind noise, and the liking. Cars/trucks/semi's with loud exhaust systems or engines were greatly diminished, and you no longer heard that "woosh" sound as you would pass vehilcles on a 2-lane road. I ripped off the cheap absorbant backing on the carpet, to make more room for the better neoprene/ closed cell foam for sound absorption. Foam on the floor and rear cab wall will greatly reduce the amount of engine/transmission/exhaust noise that radiates through the cabin floor. All of these nuances gone allowed for a much more peaceful interior that would allow to just enjoy the music while driving.
Finally, rattle pad was added to the door panels, behind the A-pillars, third door, and other small areas that I thought could pose a problem. Again, I did not have a big problem with rattles/vibrations in the first place, so I did not notice a huge improvement in this area. More for just peace of mind.
I hope that better explains what each material will do in certain areas of the vehicle, so that you can focus more on trouble areas if needs be.