Prior to installing these speakers, did you have this harshness? I ask b/c if you installed new speakers in the OEM locations and you didn't have this harshness before - it's the speakers. If you did have harshness before, it's the location.
We'll pretend that the harshness is new as that'd may be easier to solve than relocating speakers.
Did you change anything along with the speakers? A gritty DAC in a new HU could be the issue. Also, what's your source material? If you're playing compressed music you can run into weird things too as not all MP3's are created equal. Lastly, and this is probably the most likely issue, have you thought that the tweeter isn't the problem? I wouldn't be surprised at all if it's actually the mid being a little 'peaky'. Boston Acoustics Pro series speakers are notorious for this; everyone says the tweets are harsh but when you EQ the mid they sound gorgeous.
If you're using a well recorded CD (not something burned) and are having no luck with EQ'ing the tweet; start messing around with 800-2k on your EQ to see if you can tone down the mid.