yea 4 channel amps usually have two different crossover features, lowpass and highpass or fullrange. hook your components to channel 1 and 2, and there should be a crossover for those two channels, set that to fullrange. then hook your 8's up to channel 3 and 4, and there should be another crossover for those two channels, you want to hook a SUBWOOFER OUTPUT from your headunit to this channel. if you dont have a headunit that has front\rear\sub outputs, and only front\rear, then hook the rear to that channel. set that crossover to lowpass filter and get to as close to 80~150hz as you can.
if you subs are dual 4 ohm, or single 4 or 8 ohm, the will work. dual 4 would be better. single 2 ohm would be the best.
then you should be all set.