I've tried to find something similar to my problem, but was not successful. I have an infinity 4 channel amp powering 4 6x9's. When I plug 2 channels in (Pioneer) head unit there is no alt noise or hum. When I plug the other 2 in, all 4 of them make noise. I also used an old 2 channel amp I had and there was absolutely no noise when hooked up. I've tried everything. Moved power cable away from signal cables. Tried 4 different ground spots. Bought different rca's. Grounded head unit with amp. Please help!!!