When designing a dual sub 4th order bandpass enclosure, it's important to get both ported chambers the exact same volume. If the subs are not facing eachother, the cone of one sub would be in its ported enclosure, while the motor of the other sub would be in its ported enclosure. This would offset the volume in the ported side. Changing that volume changes how the box sounds, so one side would sound different than the other. I know you can compensate by increasing the size of the ported side where the sub has the motor in the sealed enclosure, but the problem is that you do not know the exact displacement of the motor side of the sub. So your volumes won't be equal. Would it make a huge impact? Probably not. But I don't think it's a good idea.