I have been running a 4" mid and 6.5" midbass for years and I am happy. I run the following crossover points:Subwoofer: 80Hz 24dB/oct LPF
Midbass: 63Hz 24dB/oct HPF and 250Hz 24dB/oct LPF
Midrange: 315Hz 24dB/oct HPF
Tweeter: 4kHz 24dB/oct HPF
I run the mid without a LPF because it is off axis in the kick and has a natural roll off that I verified with my RTA. When on-axis I varied the LPF frequency and slope but minimum overlap was preferred.
Most 6.5 can easily play down to 63Hz, and I don't see a need to HPF lower. The benefit is to run the midbass in the door where you have sufficient airspace, but you can place the midrange for better PLD or ITD.