heres the only way it will work, but will be ghetto looking as hell. but if u really wanted to do that i would add an second amp or either 4 cheap amps, then build an box that each subwoofer is in its on chamber and port. then you get an tru rms volt meter. gain match the amps so that each pair of subs is getting around the same amount of power. basically you would pretty much have too turn the gain up way more on the amp/amps that is running the dual 4 ohm subs being that the ohm load would be more than the dual 2. i dont reccomend this, but best thing would be to get an stronger second amp/amps and gain match it taht way. put the stronger amp on hte dual 4's. ive actually ran mix matched amps with differnt power ratings and had good results. but like i said i set the amps so that they did similar power, plus each sub had its own chamber.