I'm kind of on the run so I'll try to get through this quickly.
First thing that is critical in understanding is how they are derived mathematically. Note that there are only 5 basic thiele/small parameters that all others are derived from; these are BL, Cms, Re, Sd, and Mms. So...
Qms = Sqrt(Mms)/(Rms*Sqrt(Cms))
Qes = Re*Sqrt(Mms)/(BL^2*Sqrt(Cms))
Qts = Qes*Qms/(Qes+Qms)
First thing that is abundantly clear is how Qes dominates the total Q of a driver. Obviously changes in the Qes will have the greatest impact on Qts.
Looking at the equation for Qes, it's very easy to define. A lot of people use Qes as a method of describing motor strength (ie. low Qes means high motor strength) but that is simply an inaccurate statement. Yes, low Qes *may* indicate high BL (as seen in BL^2 as a divisor) but it may also indicate very low Mms. Realistically, it represents the electromagnetic ratio of energy stored vs. power dissipated. Again, the equation clearly demonstrates that:
A doubling of Re will result in a doubling of Qes.
A quadrupling of Mms will result in a doubling of Qes.
A doubling of BL will result in a quartering of Qes.
A quadrupling of Cms will result in a halving of Qes.
Looking at the equation for Qms, it is equally easy to define. We can see that:
A quadrupling of Mms will result in a doubling of Qms.
A doubling of Rms will result in a halving of Qms.
A quadrupling of Cms will result in a halving of Qms.
Qms and Qes are valuable only in that they provide you Qts. In my opinion, they don't really hold their own inherent importance as they only relate to half of the total damping characteristics of a driver. Using Qts, it is easier to identify an ideal enclosure for a driver, in terms of both enclosure orientation (ie. sealed, bass-reflex, etc.) and in terms of the size of the enclosure.
When determining the best enclosure orientation, however, there are many factors to be considered. Quite often, you will here people utilize the EBP of a driver in a process of elimination (EBP is given by Fs/Qes and comparing against empirically suggested values). To me, EBP is a useless extra calculation: the same basic parameters used to calculate EBP are utilized in Qts, thus, if we can determine the appropriate enclosure for a given Qts, there is no need for an EBP. However, as with all things, there is no specific answer and the enclosure is largely application dependent.
In a traditional sense, many people find a high Qts (0.5 or above) indicative of a sealed or infinite baffle enclosure; Qts 0.4 to 0.5 is often considered the middle ground between sealed and ported, while Qts less than 0.4 is often considered most suitable for a bass-reflex or higher order bandpass design. Low Qts in any enclosure utilizing a port is probably a good idea; the driver will see an increase in resonance and the damping provided by a low Qts design is worthwhile. However, low Qts drivers are proving more appealing in sealed enclosures as of late. The 15" Mag from Stereo Integrity is a fine example of this. Likewise, very low Qts designs are proving very appealing in infinite baffle applications, so long as Fs and the inherent low end extension is sufficient.
These are just generalizations and we can probably go into a bit more depth if you'd like. Let me know what you think and maybe provoke some further thinking on my part, if you don't mind. Anything need clarification, correction, or expansion?