i believe what you are trying to say is the amp's power wire and the RCA's going from the head unit to the amp. and yes the RCA's are prone to picking up noise from any electrical power source, power wires, fuse box, electric motors, etc.. the better quality rca you get the better shielding it will have but you still want to avoid any electrical source you can. that is why it is advised to run the power wire down one side of the car and the RCA's down the other.