Rule No. 1Your first fantasy rule to draft by is you must go running back/running back in the first two rounds. Look, it's all about depth. In a standard ESPN 10-team league, you have to play one quarterback and two wide receivers, but can play up to three running backs. The difference between the No. 1 quarterback last season (Peyton Manning) and the No. 10 (Vince Young) averaged out to just five points per game. Yet the difference between last season's No. 1 running back (LaDainian Tomlinson) and the No. 30 back (Julius Jones) was 14 points per game. It's two field goals a week versus two touchdowns. There's a lot of depth at quarterback and at wide receiver. You can get a productive one in the later rounds, but if you take a quarterback or receiver in the first two rounds, in Rounds 3 and 4 you'll find yourself saying things like "Uh, is Samkon Gado still available?" And no one wants that.