Hooking up either sub will be exactly the same process. That amp can be run with an ohm load of 1, 2, or 4 ohms. The lower the ohm load, the more power you can get out of it. So if you are choosing between a 2 ohm or a 4 ohm sub, then go for the 2 ohm. You will get about 625 watts at 2 ohms. You will get only 312 watts at 4 ohms, and if you can get a 1 ohm sub you can get about 1250 watts from that amp. Those numbers are what Kicker claims, not exact readings. I assume these subs you're talking about are single voice coil? Sorry, I don't know too much about mainstream brands.