It can be done, with the subs, you would want to most likely wire them into a series, if you get 2 4 ohm, or 2 DVC 2ohm, if you were to get 2 DVC 4ohm subs, wire each sub into a series to present an 8ohm load, and you can either wire them into a series and present a 16ohm load, or wire them into a parallel and present a 4 ohm load. (I think that's possible, I'm not sure). Most home audio receivers have 8ohm loads, but some do have 4ohm loads. Just make sure you get the appropriate receiver, and wire the speakers to the appropriate load. I had a car stereo being used as my home stereo, but I used a 12V battery charger, and used EVERYTHING for a car stereo, worked great too.
P.S. My car stereo turned to a home stereo was an old Pioneer HU, Kicker by Stillwater Designs 6" speakers, and some home audio tweaters, paired with a single 12" Depth Charge and a 400W Depth Charge amp, and that thing pounded, until my roommate moved out and stole it... I wish I could find some of the Depth Charge subs, not to thread jack, but does anyone know who they were made by? I've heard Fultron makes them, and I hear Memphis made them?