One set of RCAs can feed 2 amps (or more I'd immagine, but each time you split that signal you are gonna loose voltage to any given amp).. If the HU only has one set, I'd immagine you can't do any 'fading' adjustments on it.. When you have 2 sets, one is for front and one for back.. you can 'fade' between them (maybe, otherwise I see no point in one being front and one back, they would both be the same).. Some have 3, one front, one back, and one that's designed for just subs..
So, depending on what you think you need for amps, you can probably get away with just 1 set of pre-amp outs.. If you are just gonna run subs, 1 set is fine...