Speakers cones that are hitting the back of the seat will off center the voice coils and the coils or former will rub against the pole piece, thus creating a flat dead spot on the voice coils until one day, poof, blown subwoofer. Resistance on the ground return can be equated to this. You head into Subway, eat a foot long sub and then have your butt crack sewn half shut, get the picture. Electricity is an albebra equation, what you do to one side you must do to the other. The ground is the most important wire in the system.
Take a dmm and set it to read resistance in ohms. Disconnect the ground wire from the amp. DO not touch the dmm probes or the wire. Make sure the bare wire is not in contact with the vehicle metal. Take one probe from the meter and connect it to the neg terminal on the battery (have a friend hold it there), take the other probe and attach it to the bare wire end of the ground wire that was attached to the amp. If the probes do not reach you can use a length of speaker wire as a jumper cable. What is the reading in ohms that you get?