Panel Isolator - for areas like the space between the trunk lid and the stamped reinforcing fibs that hang below it. You can fill the gap with expanding foam to lock the sheet metal in place and stop the pieces from rattling against each other. Still nead to use traditional sound deadener on the sheet metal to eliminate resonance.
Gap Filler - for areas like quarter panels, after deadening the sheet metal, to fill the voids and stop the transmission and distortion of sound that you would otherwise get.
It is really useful stuff, but permanent, messy and potentially dangerous. As pointed out above, do no get it anywhere you don't want it. Don't use it anywhere you may need to get to later - you will not be able to get there. The strength of the expansion is very strong. If you shoot it into an area where excess can't escape, overfilling will bend sheet metal as it expands.
You also need to plan your work carefully since the can will seal itself off and become useless after a few minutes. You can't use some and then retart the can 1/2 hour later.
You want the polyurethane stuff, not the latex stuff. The latex will hold moisture and lead to rust.
Just one tool among many. Not a substitute for vibration dampers and sheet foams.