First off
Screws are not holding your box together in the end, the glue is. Glue forms a bond that is stronger than the wood is bonding. On top of that too many screws risk the integrity of the wood.
Because ppl dont get this It's in bold.
YOU NEED NO SCREWS IF YOU HAVE PLENTY OF CLAMPS OR USE PROPER JOINTING TECHNIQUES
Secondly
A butt joint is not the best joint out there, yet its the most common because it's the easiest. A Dovetail, Baton Reinforced butt, mortise and tenon, Biscuit joints, miter and spline insert, miter lock, miter rabbit, milled corner, etc... are better for airtight seals.
The easiest being a Baton insert glued in the corner of the Butt joint
This provides a much better airtight seal even if your cuts arent perfect. For audio usage its best to cut the baton diagonally into a triangular wedge.
Even then I use a brad nailer. I am not going to predill anything, too much of a hassle. Clamps arent that expensive, not if you know where to buy them(Harborfrieght.com) I've bought 32-36" clamps for 3 dollars on sale there.