If you predrill the screws prior to aplying the glue you don't need clamps. I've built tons of boxes without using the first clamp by screwing it all together. The screws provide the clamping force to give the glue the best potential for a good bond.Okay people, screws are not a replacement for clamps, let alone glue. You lay down your glue, clamp it tightly, then screw the wood together to hold the clamped bond while you go about your other business on the box. Otherwise, you won't get a chemical bond and will only have a strong physical bond.
Chemically bond what to what? Wood glue soaks into the wood and then hardens. It is designed for porous materials becuase the fact that it soaks in is vital to the joint strength. It has a low adhesion compared to something like epoxy which uses the strenth of the adhesive bond to make a strong joint. In a proper wood glue joint, the result is a composite joint. The glue is the binder and the wood itself is the matrix. The result is something akin to a layup of fiberglass where the resin is integral to the finished product, but that is still completely different than a chemical bond.Wood glue doesn't make a chemical bond..? I'm going to need to see some proof of that because not only have I heard nothing less than wood glue making a chemical bond, but my grandfather owned a woodworking mill and told me that wood glue makes chemical bonds, and he was in the business for about 50 years.