The stronger signal is only to help you get a cleaner signal to the amp. The fact that it doesn't accept over 2v is moot becuase voltage will drop through the RCAs as well as the 5v is only when the stereo is at max with all settings at max.
Also, you want to aim at 75w, not 300. It's the watts per channel, not total. Also, the fact that the speaker can handle more power than the amp can provide is moot too because, oh well. It doens't get powered to full. It can still reach full performance with less power depending on the install.
1) Set hu to max volume you usually listen to music at.
2) Sqrt(Power*Resistance) = Voltage
sqrt(75x4)=voltage
17.3205081=v
Anything higher than 17.3205081 will make the amp's signal to the speaker clip which can damage the amp.
3)
http://www.teamtreo.com/view.php?showme=Free_Test_Tones
Download and burn a test tone to cd. 60hz like Jmac said is good. Play this tone in your car.
4) While the tone is playing, put a dmm on channel 1 postive and negative
5) adjust the gain until the dmm reads as close to 17.3205081 without going over.
6) adjust other channels as needed
7) hook up your speakers and you are good to go
Remember, if the amp puts out more than 75 rms then it will be a clipped signal which causes damage. Damage = b+a+d. The fact that the speakers can handle more doesn't mean anything when your amp can only put out so much power.