If you're on a tight budget, a single 4-channel amplifier could work beautifully. I'd recommend a class D amp that can give you 300-500watts in bridged mode. I have been using PPI Phantom P900.4 (same as Soundstream TN4.900d), rated for 450watts in bridged mode. I have been happy with the output, and the amp runs only warm. Plenty of subwoofers will get loud enough on this power. Of course, if you're willing to spend twice as much money, having two amplifiers would be better, specially if you listen primarily rap, dubstep, etc, anything with "synthetic" bass. Power is cheap, it's easy and cheap to run 1000watts to the sub stage these days.