All four in series would be a 16 ohm load, and any amp wouldn't put out jack at that high of resistance. I would think you could wire two in series or parallel, then wire the pairs in parallel or series respectively (someone correct me if I'm wrong). Either way you would have a single four ohm load. You could wire 3 in parallel, then you would have a 1.33 ohm load if you amp can handle a load that low, not all can. You have several options, check to see how low of a load your amp can take, that will determine the best setup. Hope this helps.