Becuase the wire size is based on how many amps "flow" thru it. A 1/0 wire can have 300 amps of power flow through it before it loses integrity(if you will) and starts to fail. Since you don't want the wire to fail, you fuse it at the maximum amount of amps it can handle, hence a 300A fuse.
Every other wire out there has a maximum amp number that it can handle, and you would fuse those wires according to the max amps...