One amp is digital,one amp is analog.The 345 and the 450-f are both 4 channel amps.The 450-F produces 70 watts @ 4 ohms and 100 rms @ 2 ohms.The 345 produces 75 watts @4 ohms and 85 watts@ 2 ohms.I own the 450-f and have it at 2 ohms running 4 type 'r' co-ax's for the rear fill.I have it running 70 rms at 4 ohms for my type 'R' components in my front doors.The sub amp is an mrd-1005 powering 2 JL 12/w-3-3-4 in a vented enclosure.The source unit is an ALPINE 9847.WHICH AMP IS BETTER???They are both solid amps.There is not that much difference in cost.One is analog, one is digital.The choice is yours!!Good luck! o2 SENTRA out...............