your amp should have 2 seperate gains... one for the first 2 channels, one for the second 2.
you'll do it for each set of channels... but you can do it on one channel per set... i would check each channel seperately, but of channel should be right around the same...
and you'll do it by what each channel is rated at, so if you'll be running it at 70@4 then your going to be SQRT(70*4)
hope that helps