When i had my Pioneer 6800mp installed, i had horrible noise through all four speakers, but sub/amp was fine. I searched around on here and found that this is a common Pioneer problem. Grounded the HU to a solid, fairly accessible piece of metal behind the dash, and the problem was gone. I have also heard of other folks running a ground from the HU to the rear and using the existing amplifier ground surface, as was stated earlier. Also, i second that if there is no metal behind your dash that is accessible or solid, run a ground straight to the negative terminal on your battery under the hood. Any one of these solutions should solve your dilemma. Good luck, and hope it all works out!
G